Dedicated to Improving Cancer Imaging and Patient Outcomes

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What are Radio-Pathomics?

Radio-pathomic mapping is an emerging field in medical imaging that combines radiomics and pathomics to create a more comprehensive understanding of diseases, particularly in cancer research and diagnosis. The goal of radio-pathomic mapping is to improve disease diagnosis and prognosis, enhance treatment planning and monitoring, provide more personalized medicine approaches, and identify new biomarkers for diseases. This technique is particularly promising in oncology, where it can help characterize tumors more comprehensively, potentially leading to better treatment strategies and outcomes.

In our lab, we combine multi-parametric magnetic resonance imaging (MP-MRI) with digitized histological samples to create these maps. Clinical imaging and treatment history is acquired from patients who are consented to our studies. For our brain cancer tumor probability maps (TPMs), pre- and post-contrast T1-weighted images, FLAIR, and ADC are combined with large format samples taken at autopsy to detect tumor outside of contrast enhancement. For our prostate cancer radio-pathomic maps, T2-weighted images and ADC are combined with histo-morphometric features calculated from whole-mount prostate samples taken following radical prostatectomy. These maps give us a unique insights into the underlying pathology non-invasively.

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Check out this video demonstrating out online digital pathology and radiology platforms, OMERO and XNAT